Richard Hardstone, PhD

Richard Hardstone, PhD

Research Fellow
Group of David Lin, MD

Massachusetts General Hospital

Biography

Richard Hardstone is a Research Fellow in the Laboratory for Translational Neurorecovery of David Lin, MD (Dept. of Neurology, Massachusetts General Hospital). His research interests include developing neurophysiological biomarkers and computational models to characterize healthy and impaired movement in stroke, and understanding the self-organizing dynamics of neural activity and behavior.

Interests

  • Sensory Perception
  • Signal Processing
  • Computational Modeling
  • Dynamical Systems

Education

  • PhD in Neuroscience, 2016

    VU Amsterdam

  • MEng in Computing, 2006

    Imperial College, London

Skills

Java

Experienced

MATLAB

Experienced

Python

Basic

Human Electrophysiology (ECoG, M/EEG)

Experienced

Neuroimaging (fMRI)

basic

Neurostimulation (tDCS)

basic

Digital Signal Processing

Experienced

Statistics

Experienced

Linux Server Administration

Experienced

Experience

 
 
 
 
 

Research Fellow

Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital

Dec 2021 – Present Boston, MA

Projects include:

  • Characterizing longitudinal post-stroke EEG and its relationship to motor recovery
 
 
 
 
 

Post-Doctoral Fellow

Neuroscience Institute, NYU Langone Health

Mar 2016 – Aug 2020 New York, NY

Projects included:

  • Recording and analyzing data from cognitive tasks performed by patients implanted with intracranial electrodes
  • Understanding the mechanism of how lifelong perceptual priors influence object perception (Computational model)
  • Effect of hippocampal interictal epileptiform discharges (IEDs) on memory
  • Scale-free activity analysis of LFPs recorded from laminar probes implanted in awake mouse somatosensory cortex
 
 
 
 
 

Pre-Doctoral Fellow

National Institute of Neurological Disorders and Stroke (NINDS)

Aug 2015 – Feb 2016 Bethesda, MD

Projects included:

  • Recording and analyzing data from a visual bistable perception task in healthy subjects (MEG)
 
 
 
 
 

Doctoral Candidate

Center for Neurogenomics and Cognitive Research, VU Amsterdam

Mar 2010 – Mar 2015 Amsterdam, Netherlands

Projects included:

  • Computational Modeling of Neuronal Oscillations and Avalanches
  • Characterizing Resting state Cognition
  • EEG-based Neurofeedback for Insomnia

Recent Posts

Understanding long-term priors influence on visual perception

Priors learnt from lifetime experiences powerfully influence perception. Using invasive brain recordings in neurosurgical patients, we show that when perception is congruent with a long-term prior, there are increased top-down influences in the ventral visual stream, whereas bottom-up input is enhanced when perception is incongruent with the long-term prior.
Nov 1, 2021 1 min read
Understanding long-term priors influence on visual perception

Prediction of behavioral improvement using fE/I algorithm, in randomized controlled trial testing Bumetanide in Autism Spectrum Disorder

Bumetanide exerts neurophysiological effects related to clinical changes in more responsive subsets, in whom prediction of improvement was feasible using Functional Excitation/Inhibition method applied to EEG .
Sep 8, 2021 1 min read
Prediction of behavioral improvement using fE/I algorithm, in randomized controlled trial testing Bumetanide in Autism Spectrum Disorder

Novel biomarker for estimating Excitation/Inhibition

Balance between excitation & inhibition is a key principle for neuronal network organization & information processing, but has been difficult to quantify in humans. We developed a method to estimate E/I ratio non-invasively from ongoing oscillations.
Jun 13, 2020 1 min read
Novel biomarker for estimating Excitation/Inhibition

State dependent responses require critical-state dynamics

Why do we sometimes hear a quiet sound from across the room, but other times miss someone calling our name when they are standing right next to us? Our perception depends not only on the stimulus properties, but also on the current functional state of the brain.
Jun 1, 2020 1 min read
State dependent responses require critical-state dynamics

Clinical applicability of fE/I biomarker will be tested in new grant from NWO

Together with clinicians and researchers from Utrecht, Nijmegen and Twente, CNCR researchers Verhage, Cornelisse, Meijer (FGA) and Linkenkaer-Hansen (INF) received a €1,8M grant to improve personalized medicine for children with autism. A novel EEG biomarker of Excitation/Inhibition (fE/I), developed by Richard Hardstone in the team of Linkenkaer-Hansen, will be used to group children with ASD based on the balance between excitation and inhibition in their brain.
Jun 18, 2019 1 min read
Clinical applicability of fE/I biomarker will be tested in new grant from NWO
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Recent Publications

Quickly discover relevant content by filtering publications.

Long-term priors influence visual perception through recruitment of long-range feedback

Richard Hardstone, Michael Zhu, Adeen Flinker, Lucia Melloni, Sasha Devore, Daniel Friedman and, Patricia Dugan, Werner K Doyle, Orrin Devinsky, and, Biyu J He
PDF DOI

Prediction of Behavioral Improvement Through Resting-State Electroencephalography and Clinical Severity in a Randomized Controlled Trial Testing Bumetanide in Autism Spectrum Disorder

Erika L. Juarez-Martinez, Jan J. Sprengers, Gianina Cristian, Bob Oranje, Dorinde M. van Andel, Arthur-Ervin Avramiea, Sonja Simpraga, Simon J. Houtman, Richard Hardstone, Cathalijn Gerver, Gert Jan van der Wilt, Huibert D. Mansvelder, Marinus J.C. Eijkemans, Klaus Linkenkaer-Hansen, Hilgo Bruining
PDF DOI

Effects of hippocampal interictal discharge timing, duration, and spatial extent on list learning

Beth Leeman-Markowski, Richard Hardstone, Lynn Lohnas, Benjamin Cowen, Lila Davachi, Werner Doyle, Patricia Dugan, Daniel Friedman, Anli Liu, Lucia Melloni, Ivan Selesnick, Binhuan Wang, Kimford Meador, Orrin Devinsky
PDF DOI

Measurement of excitation-inhibition ratio in autism spectrum disorder using critical brain dynamics

Hilgo Bruining*, Richard Hardstone*, Erika L. Juarez-Martinez*, Jan Sprengers*, Arthur-Ervin Avramiea, Sonja Simpraga, Simon J. Houtman, Simon-Shlomo Poil, Eva Dallares, Satu Palva, Bob Oranje, J. Matias Palva, Huibert D. Mansvelder, Klaus Linkenkaer-Hansen
PDF DOI

Pre-stimulus phase and amplitude regulation of phase-locked responses are maximized in the critical state

Understanding why identical stimuli give differing neuronal responses and percepts is a central challenge in research on attention and …
Arthur-Ervin Avramiea*, Richard Hardstone*, Jan-Matthis Lueckmann, Jan Bím, Huibert D Mansvelder, Klaus Linkenkaer-Hansen
PDF DOI
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Contact

  • 101 Merrimac Street, Boston, MA 02114
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